Attention: Autism Science Nerds. One of the best reviews on autism neurology I've read in a while.

[Neonatal RRT]

Four Social Brain Regions, Their Dysfunctions, and Sequelae, Extensively Explain Autism Spectrum Disorder Symptomatology - PMC.

 

[Rocco]

Fascinating information, thank you for sharing that.

 

[FilterFreq]

Now I can say "I lack a filter!" and mean it in two entirely different ways!

 

[Neonatal RRT]

FYI: On my other thread about serotonin, psilocybin, and autism, I added information regarding the role of the anterior cingulate cortex (ACC) which acts as the primary "switchboard" for these 4 major areas of the brain. The ACC is heavily populated with the 5-HT2A receptors (as opposed to 1A, 1B, 1C receptors where SSRIs bind to). Psilocybin breaks down to psilocin in the liver and binds to the 2A receptors in the ACC with a higher affinity than endogenous serotonin, suggesting a therapeutic role for psilocybin in autism.

There appears to be genetic polymorphisms in the serotonin binding and transport system in many autistics, and is why our endogenous serotonin might not be binding as well to our 2A receptors as it should be, leading to many of the common symptoms we have.

The PSILAUT study, which is just beginning, will one of the first to put psilocybin in a therapeutic role for autism.

 

[Outsider]

Four Social Brain Regions, Their Dysfunctions, and Sequelae, Extensively Explain Autism Spectrum Disorder Symptomatology - PMC.

This is an interesting summary of research on autism. As a data analyst, I'm going to take a look at 3 articles listed in the reference section to evaluate the authors' methods of statistical analysis and collection of data. Hopefully, they are better than the ones about the COVID pandemic articles that I encountered in the past,

One thing about the article I don't like, though-the author wrote that autism is characterized by incorrect understanding of the reality, which contradicts my observations of autistic people. - I didn't discover any intellectual abnormalities in them. My independent opinion matters because it is not biased, I am NT.

 

[Misty Avich]

It was too complicated for me to read so I lost focus.

 

[Neonatal RRT]

This is an interesting summary of research on autism. As a data analyst, I'm going to take a look at 3 articles listed in the reference section to evaluate the authors' methods of statistical analysis and collection of data. Hopefully, they are better than the ones about the COVID pandemic articles that I encountered in the past,

One thing about the article I don't like, though-the author wrote that autism is characterized by incorrect understanding of the reality, which contradicts my observations of autistic people. - I didn't discover any intellectual abnormalities in them. My independent opinion matters because it is not biased, I am NT.

Perhaps, I may be wrong, but my interpretation here when the author wrote that "autism is characterized by incorrect understanding of reality" can be taken a few ways. This statement might not be interpreted in a way that, perhaps, most people might think. Let us not allow our negative bias jump to false conclusions here. What I suspect what is meant by this is that one of the symptoms of autism is difficulties with "theory of mind", that may result in difficulties with perspective-taking in what may more commonly referred to as "mind blindness" as it pertains to interpersonal interactions. For example, I have been with my wife for 40 years, yet I always have to ask her what she is thinking, her interpretations of things, intent, etc. I will never "know" my wife. I cannot predict her behaviors or thinking in any way. All I have is my own thinking, which might not be correct in certain situations. Another aspect of autism is that autism is one of the "low-dopamine" neurological conditions. With that, there is an enhanced negativity bias and sensitivity, as well as a predisposition towards depression. Depression often leads to an altered sense of reality.

 

[Outsider]

Perhaps, I may be wrong, but my interpretation here when the author wrote that "autism is characterized by incorrect understanding of reality" can be taken a few ways. This statement might not be interpreted in a way that, perhaps, most people might think. Let us not allow our negative bias jump to false conclusions here. What I suspect what is meant by this is that one of the symptoms of autism is difficulties with "theory of mind", that may result in difficulties with perspective-taking in what may more commonly referred to as "mind blindness" as it pertains to interpersonal interactions. For example, I have been with my wife for 40 years, yet I always have to ask her what she is thinking, her interpretations of things, intent, etc. I will never "know" my wife. I cannot predict her behaviors or thinking in any way. All I have is my own thinking, which might not be correct in certain situations. Another aspect of autism is that autism is one of the "low-dopamine" neurological conditions. With that, there is an enhanced negativity bias and sensitivity, as well as a predisposition towards depression. Depression often leads to an altered sense of reality.

Being a Positivist (Empiricist) I subscribe to Behaviorism because it is a psychological branch of Positivism. In Behaviorism the phrase “incorrect understanding of reality” means that a person takes a course of action that either puts him/her in physical danger or, while being harmless, leads to a waste of time due unrealistic goals.

My friend has a mild case of schizophrenia. Being an Army veteran, he wants to get an appointment with the Secretary of Defense (in Europe this is an equivalent of Minister of Defense) to discuss the “government lies” about almost everything. He believes that the Secretary of Defense will be interested in having a conversation with him, and tries really hard to set a meeting with this high-ranking. This is a classical case of incorrect understanding of reality.

People, both autistic individuals and NTs, often make mistakes regarding personal interactions, but I don’t think that a psychologist would classify communication difficulties as “incorrect understanding of reality”.

 

[Neonatal RRT]

Being a Positivist (Empiricist) I subscribe to Behaviorism because it is a psychological branch of Positivism. In Behaviorism the phrase “incorrect understanding of reality” means that a person takes a course of action that either puts him/her in physical danger or, while being harmless, leads to a waste of time due unrealistic goals.

Well, by that definition, it could explain some of us, some of the time.