Yeah, from my knowledge on drug stuff, here is a list of things which I hope are helpful in some way:
- Serotonin allergy, as far as I'm aware, is not a thing (I've done a quick database search, and nothing related to it is coming up, instead it's linking to the theory I explain a bit later in this paragraph). As serotonin is a naturally occurring neurotransmitter in the body, it most likely wouldn't be able to elicit an allergic effect or intolerance effect as far as we currently understand these elements. What is a hypothesis, which is debatable and generally not accepted by the medical community, is the 'leaky gut hypothesis' (have a read about it, as I haven't done too much on it, but I believe that is one explanation to say that the dose of the drug that may enter an autistic person's system is significantly higher than intended and so causes more side effects - as I stated, there isn't much evidence for it and so is generally not accepted by the medical community).
- Beta-blockers are a treatment for the symptoms of an anxiety disorder, and through treating the physical effects can help you to relax mentally, which is really good (propranolol is the only medication I take any more for anxiety when I am getting a bit panic-attacky and it does help distract me from it and help me to calm down a bit).
- The serotonin theory is just one theory around depression, and it is the one with more evidence, but as rightly stated, it is not completely proven. But that is kinda like a lot of things in science, we work with what we think is right at the time and see what happens and SSRIs do work for some people, but also they don't work for some people.
- Citalopram (ie. Lexapro) has a fairly long half life, and works by building up a cumulative dose over time. The general guidance for antidepressants is that it takes between 4 and 6 weeks to start to see an effect, and in the meantime you can have the side effects of worsening depression and anxiety, which can suck a lot. But if you get through to the 6 week period then it starts to get better. From my experience it was more like 8 weeks before I started having a proper effect, and that is not uncommon.
Yeah, medication for neurotransmitter levels is currently not at a stage to work wonderfully, as our neurotransmitter release is so fine tuned to get the brain to work properly normally, that adding in an SSRI is to some extend like hitting a circuit board with a hammer, and so starting with a lower dose and slowly building up may be a good way to go. But if you are feeling really desperate then it may be a good idea, as others are suggesting. There is the key thing though that medication alone will not help. When I was on an SSRI I saw it as a blocker to stop me from wrapping myself up in more thoughts and so I had the time to deal with the thoughts I was having and reach some sort of a solution, that may not be perfect, but at least when I then went off of the medication I was more able to stop thoughts after that and control what was happening. But just taking an SSRI will not make things feel really better so to say from my experience (as the reason I went off it was similar to other people here, I felt like there was something weird happening and messing around with my neurobiology and I did not like it so I told my GP and withdrew myself). They will make things feel better in some ways, but I didn't like it ultimately so stopped. But it does have different effects with different things.