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What Causes Muscle Wasting?
Medically reviewed by Elaine K. Luo, M.D. — Written by Ann Pietrangelo —Updated on August 24, 2019
Muscle wasting or atrophy is usually caused by not being able to regularly exercise your muscles. Your inability to move may be be due to an injury or an underlying health condition.
Muscle atrophy is when muscles waste away. It’s usually caused by a lack of physical activity.
When a disease or injury makes it difficult or impossible for you to move an arm or leg, the lack of mobility can result in muscle wasting. Over time, without regular movement, your arm or leg can start to appear smaller but not shorter than the one you’re able to move.
In some cases, muscle wasting can be reversed with a proper diet, exercise, or physical therapy.
Symptoms of muscle atrophy
You may have muscle atrophy if:
- One of your arms or legs is noticeably smaller than the other.
- You’re experiencing marked weakness in one limb.
- You’ve been physically inactive for a very long time.
Call your doctor to schedule a complete medical examination if you believe you may have muscle atrophy or if you are unable to move normally. You may have an undiagnosed condition that requires treatment.
Causes of muscle atrophy
Unused muscles can waste away if you’re not active. But even after it begins, this type of atrophy can often be reversed with exercise and improved nutrition.
Muscle atrophy can also happen if you’re bedridden or unable to move certain body parts due to a medical condition. Astronauts, for example, can experience muscle atrophy after a few days of weightlessness.
Other causes for muscle atrophy include:
- lack of physical activity for an extended period of time
- aging
- alcohol-associated myopathy, a pain and weakness in muscles due to excessive drinking over long periods of time
- burns
- injuries, such as a torn rotator cuff or broken bones
- malnutrition
- spinal cord or peripheral nerve injuries
- stroke
- long-term corticosteroid therapy
Some medical conditions can cause muscles to waste away or can make movement difficult, leading to muscle atrophy. These include:
- amyotrophic lateral sclerosis (ALS),also known as Lou Gehrig’s disease, affects nerve cells that control voluntary muscle movement
- dermatomyositis, causes muscle weakness and skin rash
- Guillain-Barré syndrome, an autoimmune condition that leads to nerve inflammation and muscle weakness
- multiple sclerosis, an autoimmune condition in which the body destroys the protective coverings of nerves
- muscular dystrophy, an inherited condition that causes muscle weakness
- neuropathy, damage to a nerve or nerve group, resulting in loss of sensation or function
- osteoarthritis, causes reduced motion in the joints
- polio, a viral disease affecting muscle tissue that can lead to paralysis
- polymyositis, an inflammatory disease
- rheumatoid arthritis, a chronic inflammatory autoimmune condition that affects the joints
- spinal muscular atrophy, a hereditary condition causing arm and leg muscles to waste away