Alright I'll ramble a bit about this but something tells me nobody will have a bloody clue as to what I'm talking about. I dont exactly see many indie-focused gamers on here.
So, Binding of Isaac, one of my all-time favorite games, here we go:
Strategies can vary depending on character choice. Well, overall approach, I guess. Most characters dont really require a specific approach, but some do:
Lilith: My personal favorite, and one of my favorite characters in any game. Lilith is unusual in that she is blindfolded... she cannot fire tears on her own (yes everyone attacks by crying real hard at things). She uses familiars to fight for her, which means her aim is weird. It is best to take a fairly defensive approach to combat, with more of a focus on familiar position than anything else. When it comes to items, anything that recharges her active item faster is important. Taking new active items is a total no-go with her. And anything that gives her even more familiars is a definite boon.
Lazarus: If anyone is gonna make a deal with ol' Satan, it's this guy. Much more likely to do that when using him, but if he does end up resurrecting he'll need some defense or a way to get more heart containers fast. Theoretically the power from the devil items will give him an edge once he's in his Risen form.
Forgotten: Well he's got a club and can do that weird ghost thing. Doesnt need many bombs and range-up items do little for him. The real trick with him is switching between skeleton dude and ghost form and understanding how to use both.
Bethany: Really, REALLY wants active items. Preferrably something that has a low recharge to it. Having any items that can cause the fear status in enemies is also helpful, to keep her wisps from getting popped as easily. Also anything that can help her not get hit. She cant use soul hearts, and that makes getting angel or devil deals harder than with most characters.
Tainted Lilith: Well first you have to get over how freaking disturbing she is. I just... how does someone think up that method of attack? I mean, "demon fetus on an umbilical cord that explodes like a Xenomorph chest burster out of her stomach and smacks things like a whip" isnt exactly what I'd call a traditional attack. Kinda gross too. Much of the art of her just makes it worse. But anyway, once you're past that nightmare, she really, really needs damage upgrades, and items that are all about tear effects do little for her. She also could do with speed upgrades of any sort as she is bloated and slow.
Tainted Bethany: The strategy is that you choose her and then you win because she's extremely overpowered.
Tainted Lost: no
And for non-specific strategies, I just take it slow and think things over. You never know what is going to appear in this game, so the decisions are different every time. Make careful choices or my character build becomes a self destructive mess. And choose the route through the game based on the build I have at the time. Dont even think about fighting Dogma, Mother, or Delirium unless I'm already quite strong at the point when the decision needs to be made.
And beyond that... I never, ever give up. Thousands of hours of both bullet-hell games and roguelikes will tend to give you that tenacity.